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KMID : 0043320170400020159
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Archives of Pharmacal Research
2017 Volume.40 No. 2 p.159 ~ p.167
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Isolation, characterization, and in rats plasma pharmacokinetic study of a new triterpenoid saponin from Dianthus superbus
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Ren Yi Na
Xu Xiao Bao
Zhang Qian Lan
Lu Yong Zhuang
Li Xi Min
Zhang Lin
Tian Jing Kui
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Abstract
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One new oleanolic acid triterpenoid saponin, 3-O-β-d-glucopyranosyl olean-11, 13(18)-diene-23,28-dioic acid, (hereafter referred to as DS-1) was isolated from the traditional Chinese medicinal plant Dianthus superbus (D.superbus). DS-1 plays an important role in the bioactivity of D. superbus. Thus, a sensitive, reliable and accurate reversed-phased liquid chromatography with tandem mass spectrometry (LC?MS/MS) in negative ion mode was developed and validated for the quantification and pharmacokinetic study of DS-1 in rats plasma. The pharmacokinetic profile showed that DS-1 was rapidly absorbed and eliminated in plasma, indicating that significant accumulation of the compound in biological specimen is unlikely. In addition, poor absorption into systemic circulation was observed after oral administration of DS-1, resulting in low absolute bioavailability (0.92 %).
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KEYWORD
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Dianthus superbus, Triterpenoid saponin, LC?MS/MS, Pharmacokinetic
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